MPS has an activating influence on the connective tissue metabolism. This caused different authors to investigate whether scar tissue is also favourably influenced by MPS.

MPS能激活結締組織代謝。因而許多作者研究了疤痕組織是否也會受其影響。

 

Schiedel reported on his experience of the treatment of hard scars with MPS. A clear softening and an increased flexibility of the tissue together with an improvement in blood flow led to good results.

Schiedel報道其用喜療妥治療硬化性疤痕的經驗。結果顯示疤痕組織顯著軟化、彈性和局部血流量增加。

 

In a double-blind study versus placebo, Shimizu et al. verified the influence of Hirudoid cream in 41 patients with hypertrophic scar formation. Hirudoid cream and placebo were applied once daily to a specific part of the scar and covered with a bandage. Parameters were the shade of color and hardness of the scar tissue, thickness and size of scar, and subjective symptoms.

在一安慰劑對照的雙盲研究中，Shimizu等人驗證了喜療妥軟膏對41位患者疤痕形成的影響。喜療妥軟膏一天一次涂抹于疤痕部位并用繃帶覆蓋。療效評估參數為：疤痕組織的色澤和硬度，疤痕的厚度和大小以及主觀癥狀。

 

Hirudoid cream was clinically superior in 76% of the cases investigated. In the other 24% of the patients no difference between the treatment groups was observed. The older the patients, the more the results were delayed. The prospects of success increased with an early start of treatment.

76％的病例顯示喜療妥的臨床療效優于安慰劑。另外24％的患者無組間差異。患者的年齡越大，起效時間越長。越早治療，療效越佳。

 

Hirudoid has been proven to significantly improve the metabolic situation in the early pressure areas when compared to placebo treatment.

經論證，對于早期受壓區域代謝的改善，喜療妥組顯著優于安慰劑組。

 

In a double-blind, placebocontrolled study Kuisma/ Tamelander investigated the efficacy of Hirudoid cream in the prevention of pressure sores in geriatric patients. The presence of broken skin was an exclusion criterion. The creams were massaged in twice daily until complete subsiding of the symptoms or for a maximum of four weeks.

在一雙盲、安慰劑對照的研究中，Kuisma和Tamelander觀察了喜療妥軟膏對于老年患者壓力性疼痛的預防作用。排除標準為表皮破損。軟膏被一天兩次輕輕地按摩入皮膚直至癥狀完全消失或最長四周。

 

 

Early pressure areas in 19 cases were evaluated in each group. With Hirudoid cream a significant size reduction, measured by planimetric evaluation of the affected areas, was observed during the 2^nd week of treatment. At the end of the study 59% of Hirudoid patients were fully healed, which was significantly superior to the rate healed in the placebo group (p < 0.05).

每組共有19個病例，并對其早期受壓區域進行了評估。通過對受累區域的測量評估顯示，治療兩周末，其大小顯著減小了。研究結束時，喜療妥組的痊愈率為59%, 顯著優于安慰劑組(p < 0.05)。